What is the level of expression of PCA3 by PIN (HG & LG) relative to cancerous tissue? My understanding that all of these categories of tissue “over”express PCA3 but the relative extent by each category is something I cannot determine in my online research.
I have had two TRUS biopsies (12 and 18 core), both negative. Have most recent PSA in the 6+ range, normal DRE, but PCA3 result of 86.9. I am due for another biopsy soon.
My concern in that the urine testing was skewed by the presence of HGPIN (one core in first bipsy) and LGPIN (several cores in second).
I have stopped using the PCA3 test because in my opinion it too unreliable to guide management of my patients.