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18F-Fluciclovine PET/CT Superior to 11C-Choline PET/CT for the Detection of a Prostate Cancer Relapse

We have all been ever increasingly aware of the weakness of our scanning technologies when it comes to both diagnosing prostate cancer and its recurrence. Given that about 1/3 of all primary treatments for prostate cancer will fail and the cancer will return it is vital that we improve our ability to detect prostate cancer [...]

Standardizing PSA Definition of Biochemical Recurrence after Radical Prostatectomy

There are multiple definitions of biochemical recurrence for prostate cancer treatment post surgery. This causes confusion both within the patient community and the medical community. It would be very helpful if we could standardize a simple measure, PSA as the biomarker for a biochemical recurrence. Standardization post surgery would give us a better way to [...]

Comparing (18)F-FACBC (anti1-amino-3-(18)F-fluorocyclobutane-1-carboxylic acid) and (11)C-choline PET/CT in Prostate Cancer Relapse

There has been a lot of hype and confusion about what is the best contrast for prostate cancer PET/CT scans. The two newest contrasts; (18)F-FACBC (anti1-amino-3-(18)F-fluorocyclobutane-1-carboxylic acid) and (11)C-choline both have their supporters and their detractors. To try and evaluate the efficacy differences between these two contrasts in men who have suffered a bio-chemical recurrence [...]

Can Radiotherapy (Radiation) for the Primary Tumors Benefit Men With Prostate CancerWith Distant Metastasis at Initial Diagnosis?

The common belief is that if you are diagnosed with prostate cancer that has already developed metastases only a systemic treatment will provide a life extending benefit. In other cancers it has been shown that the treatment of the primary tumor improves survival (tumor debulking). To find out if, in fact radiotherapy treatment of the [...]

What Is The Role Of C-Reactive Protein In The Prediction Of A Bio-Chemical Recurrence Post Radical Prostatectomy?

Periodically, some of the men in one of my support groups get locked into what they see as the importance of monitoring their C-reactive protein (CRP) serum levels to be able to predict their chances of having a Bio-Chemical Recurrence (BCR) (PSA only). The CRP measures levels of inflammation and we know that inflammation and [...]

What Is The Significance Of Prostate Specific Antigen Persistence After Radical Prostatectomy For Men With Node-positive Prostate Cancer?

It is generally accepted that a complete biochemical response (BR) of a man’s PSA immediately after surgery is an indicator of optimal cancer control. Does this also hold true for men with lymph node invasion (LNI)? Researchers performed a single institution study of 319 men with prostate cancer and LNI who were treated with surgery [...]

Positive Findings In Pelvic MRIs In Relapsed Prostate Cancer After Failed Radical Prostatectomy

There has been a lot of conversation about the role of and the use of multi-parametric MRIs in the initial diagnostic stages of prostate cancer, but little is known about its potential clinical application in the use of early salvage radiotherapy after failed radical prostatectomy. In a study to exam the potential of multi-parametric MRIs [...]

Data Supports A Radical Prostatectomy Option for Some Localized Advanced Prostate Cancer

I have often had men recently diagnosed with advanced, metastatic prostate cancer call me and ask if surgery makes any sense for them to consider. I have never been sure how to respond given that their cancer is known to be already out of their gland. In response to this common question, researchers from the [...]

What Are The Negative Prognostic Factors You Should Know When You Have A Biochemical Prostate Cancer Occurrence

Knowing the negative prognostic factors for successful treatment when you have a   a biochemical recurrence (PSA only) of your prostate cancer is important. These factors can help you make your treatment decisions because they assist you in evaluating your possible clinical outcome. In a single institutional review of  negative prognostic outcomes of salvage radiotherapy in [...]

Role of Anxiety Reduction in Men with a Prostate Cancer Recurrence

Increasingly, we have become better informed about the possible role of psychological and spiritual interventions in the treatment of cancer, specifically for this post in men with locally advanced prostate cancer. This post is limited to just discussing the possible interventions specifically in men with a Biochemical Prostate Cancer Recurrence, commonly referred to as a [...]

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