There has been a lot of hype and confusion about what is the best contrast for prostate cancer PET/CT scans. The two newest contrasts; (18)F-FACBC (anti1-amino-3-(18)F-fluorocyclobutane-1-carboxylic acid) and (11)C-choline both have their supporters and their detractors.
To try and evaluate the efficacy differences between these two contrasts in men who have suffered a bio-chemical recurrence after surgery researchers did a head to head evaluation of 100 consecutive men treated with surgery for prostate cancer and presenting with a rising PSA.
All of the men had (11)C-choline and (18)F-FACBC PET/CTs performed within 1 week and were off hormonal therapy at the time of the scans. The two contrasts were compared directly in terms of overall positivity/negativity on both a p