Non-metastatic Castrate Resistant prostate cancer patients take note. The Phase 3 PROSPER trial in patients with non-metastatic (M0) Castration-Resistant Prostate Cancer (CRPC) showed that the use of XTANDI® (enzalutamide) plus androgen deprivation therapy (ADT) significantly reduced the risk of developing metastases or death by 71 percent compared to ADT alone.
It will be a while while the FDA and EU regulatory agencies decide if Xtandi could be sold for us by nmCRPC patients. Malecare will keep you up to date.
“In patients with non-metastatic CRPC, there is a high unmet need to delay development of metastases and the progression to advanced prostate cancer. There are currently no approved systemic therapies for patients with non-metastatic CRPC in the U.S.,” said Maha Hussain, M.D., Robert H. Lurie Comprehensive Cancer Center of Northwestern University. “In the PROSPER trial, treatment with enzalutamide plus ADT delayed the development of metastases compared to standard of care ADT alone and, if approved, may provide men with non-metastatic CRPC an important new treatment option.”