The PREVAIL Trial Shows That Enzalutamide Not Only Increases Overall Survival Over Placebo, It Also Delays the Onset Of The First Skeletal Event

Analysis of the PREVAIL Trial showed that Enzalutamide (Xtandi) significantly increased overall survival and radiographic progression-free survival compared with placebo in men with prostate cancer who were asymptomatic and minimally symptomatic, chemotherapy-naive and who had metastatic castration-resistant prostate cancer (mCRPC). Now, an additional analysis of the data has shown the effect enzalutamide also has on [...]

Pain and Its Under-Treatment in Advanced Cancers

I really thought we had gotten over this problem, but an article appearing in a recent report in the Journal of Clinical Oncology indicates that the age old problem that often our doctors fail to supply adequate pain medications to advanced cancer survivors because a fear of drug addiction This attitude still hampers good survivorship [...]

Denosumab is Superior to Zoledronic Acid (ZA) for Pain Interference and Quality of Life

Men with castration-resistant prostate cancer (CRPC) and bone metastases (BM) will eventually develop debilitating pain that impacts daily functioning and diminishes their quality of life. Based on prior studies, including a phase III trial, the superiority of denosumab over zoledronic acid (ZA) in delaying or preventing skeletal-related events (pathological fracture, radiation or surgery to the [...]

Denosumab or Zoledronic Acid – Which is Superior for Pain Interference and Improving Quality of Life?

Men with castration-resistant prostate cancer (CRPC) and bone metastases (BM) will often have debilitating pain that impacts every aspect of their daily functioning thus significantly diminishing their quality of life (QoL). Finding the best drug or treatment to control the pain will allow men to have a more complete and fulfilling life as well as [...]


Leslie from the Malecare Advanced Prostate Cancer On-line Support Group made a post today warning us that there have been significant malfunctions in fentanyl patches. Fentanyl patches are used to control severe pain, especially in men with very progressed advanced prostate cancer. According to the information posted some of these patches are malfunctioning causing accidental [...]

Dealing with the Worry of Developing a Met

Every time I feel any pain, especially when it is in my chest or lower back, the little birdie whispers to me that I have finally developed a bone met. What are just the normal aches and pains from getting older sometimes seem to magnify and turn on the worry switch. It isn’t dissimilar to [...]

FDA Approves New Drug to Alleviate Moderate to Severe Pain

The U.S. Food and Drug Administration (FDA) has approved a new drug which provides relief of moderate to severe acute pain. This is great news for us, because, advanced prostate cancer often brings pain from mets and breaking bones. This newly approved drug, tapentadol hydrochloride, is delivered as an immediate-release oral tablet. It is a [...]

Pain – There Is No Reason To Be In Pain

Taking charge of your medical care not only might improve your survival, but it could also improve your life. According to a study in the September 1 issue of the International Journal of Radiation Oncology*Biology*Physics, the official journal of the American Society for Therapeutic Radiology and Oncology pain is the most common symptom of cancer, [...]