Men with metastatic prostate cancer have higher rates of inherited gene mutations than men with non-metastatic prostate cancer. Knowing about DNA mutations might help you make better treatment decisions. And you can also tell family members about their risk. Recent studies have shown that metastatic prostate cancer inherited mutations in the DNA-repair genes, such as the BRCA gene, can help [...]
African American men get more prostate cancer and more lethal forms of prostate cancer than men of other ethnicities. We assume that a combination of genetic differences, lifestyle, nutritional and medical access were the reasons for this disparity. Understanding the role of these different possible contributors is important if we are to be able to [...]
It is common knowledge that men with metastatic castration-resistant prostate cancer (CRPC) don’t all have the same disease. There are many different types or flavors of prostate cancer. These differences are involved in the genetic structure of the cancer cell its self. Some prostate cancers have mutations in the DNA repair genes (genes whose job [...]
When Angelina Jolie's double mastectomy hit the headlines in May this year there was a lot of press coverage including discussions about BRCA 1 and 2 genes. These conversations centered on women and their risk of breast or ovarian cancer. But, what about BRCA 1 and 2 in relation to prostate cancer, is there any? [...]
In today's issue of Cancer Discovery a group of international researchers report that an investigational drug had a dramatic response in animal models of neuroendocrine prostate cancer, a lethal form of the disease. The researchers pointed out that fewer than 2% of prostate tumors in men are initially diagnosed as neuroendocrine, but many of the [...]