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Did You Know That Metastatic Prostate Cancer Causes DNA Mutations?

Men with metastatic prostate cancer have higher rates of inherited gene mutations than men with non-metastatic prostate cancer.  Knowing about DNA mutations might help you make better treatment decisions. And you can also tell family members about their risk. Recent studies have shown that metastatic prostate cancer inherited mutations in the DNA-repair genes, such as the BRCA gene, can help [...]

A New Genetic Test To Help You Understand Your Risk For A Prostate Cancer Recurrence

Base on a recently published news release, a prospective study performed and funded by the commercial company GenomeDx Biosciences showed that their new Decipher Cancer Classifier test reclassifies the tumor aggressiveness in men who have had surgery as their primary prostate cancer treatment. According to the company, this newly validated test will improve clinical decision-making [...]

Understanding the Risk Factors for Hereditary Prostate Cancer – A Surprise

We often refer to prostate cancer as a family affair, or rather being passed on from father to son, etc. This is only partially true because there is still more prostate cancer diagnosed in men without any family history. For those cancers that are passed on from one family member to another it is important [...]

Myriad Genetics Attempts To Deny Patients Their Personal Genetic Information

 In 2013, Myriad Genetic failed – in a case that was heard in the United States Supreme Court - to patent the BRCA1 and BRCA2 genes.  We all have these two genes which, when they mutate, are associated with breast, ovarian and prostate cancers. If Myriad succeeded, they would have controlled patents on these genes [...]

Genetic Biomarker Predicts Peripheral Neuropathy Associated With Docetaxel Chemotherapy For Prostate Cancer

According to researchers at the H. Lee Moffitt Cancer Center & Research Institute, men with a mutation in their VAC14 gene are more susceptible to Docetaxil chemotherapy induced neuropathy and nerve pain. This debilitating side effect results from damage to the peripheral nerves and is felt by the man as weakness, numbness and pain most [...]

New Markers To Make Better Treatment Decisions For Prostate Cancer

Making treatment decisions once you have been diagnosed with prostate cancer is difficult. Often, it is impossible to accurately and reliably be able to predict the eventual course of the cancer. Prostate cancer, besides being one of the slower growing cancers, is also one of the deadliest. So good, informed decisions are vital. The original [...]

DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer Phase II Results

We know that prostate cancer is a heterogeneous disease, but most of our treatments are not based on the different molecular stratification exhibited by the disease. One of the differences we do recognize in the cancer is that some of the tumors have genetic DNA-repair defects. There has been evidence that in those cancers exhibiting [...]

More From ASCO GU 2016 – ExoDx™ Prostate(IntelliScore): A More Precise, Genetically Informed Prostate Cancer Test from a Simple Urine Sample

The constant hope and conversation of late has surrounded what is referred to as a liquid biopsy. The hope and goal is to no longer need to have an invasive needle biopsy to diagnose and stage prostate cancer. Biopsies are not accurate because there are too many false negatives, they only evaluate the actual tissue [...]

Decipher® Test Predicts Radiation Failure and Identifies Candidates for Early Radiation Therapy Following Prostate Surgery

Last year GenomeDx Biosciences  presented  data  showing that its Decipher® Prostate Cancer Classifier (the test), a genomic test, is capable of predicting the probability that a man will eventually develop metastatic prostate cancer, despite having surgery as a primary treatment for prostate cancer.  The company claims that the test out performs other existing tests of [...]

About the Important Genetic Prostate Cancer Study (UKGPCS) in the United Kingdom

Cancer is a genetic disease, so prostate cancer is a genetic problem. This statement might be the most important one we can make when trying to describe the current, overall situation we face as prostate cancer survivors! Many institutions have begun significant research studies trying to understand the actual genetic keys to prostate cancer. Prostate [...]

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