Genetics & Calcium Might Increase Risk for Prostate Cancer In the African-American Men

A study by at Wake Forest Baptist Medical Center in Winston-Salem N.C., Keck School of Medicine at the University of Southern California (USC) and the Cancer Prevention Institute of California suggests that a high intake of calcium causes prostate cancer among African-American men who are genetically good absorbers of the mineral. According to Gary G. [...]

Genome-wide Association Study Identifies a Genetic Variant Associated with Risk for More Aggressive Prostate Cancer

It is estimated that in the United States 200,000 men will be diagnosed with prostate cancer each year with approximately 20% to 30% having clinically aggressive prostate cancer. When diagnosed the standard is to consider factors such as Gleason score and tumor stage to assess a man’s prognosis, however there are no biomarkers to identify [...]

Decreased Prostate Cancer-Specific Survival of Men with BRCA2 Mutations and for Men from Breast Cancer Families

It is fairly common practice for those diagnosed with breast cancer to have genetic testing. Genetic testing is almost unheard of when men are diagnosed with prostate cancer. Current research shows that genetic testing for men with prostate cancer could provide important information about both potential treatment efficacy and prognosis. A recent look at the [...]

Towards An Understanding of the Role of Genetics in Determining Future Treatment Options in Advanced Prostate Cancer – SLCO2B1 and SLCO1B3

We have heard for a period of time that the future of cancer treatment is in genetics. Despite the hubbub, we see very little hard evidence of this in today’s current treatment decisions. Treatment still remains tied into protocols with a strong bias to following a common map. Each map does have little variances, but [...]

One Large Step for Prostate Cancer and One Very Small Step for Men – Whole Genome Sequencing for Prostate Cancer

Yesterday the Prostate Cancer Foundation (PCRF) made a major announcement, it has sequenced the of whole cancer genomes of seven different men with aggressive prostate cancer. This is a historic development in the fight against prostate cancer, however, it is a small step for those of us on the ground. The eventual goal of projects [...]

Excessive Alcohol Consumption May Lead to Increased Cancer Risk

The question: Can heavy alcohol consumption accelerate telomere shortening & does telomere shortening cause premature aging and an increased cancer risk? Many of us like to drink alcoholic beverages. I confess, I too enjoy red wind have been known to enjoy a single malt scotch on occasion. However, we always need to remember that excessive [...]

BRCA2 Mutation Indicates Shorter Survival in Men with Prostate Cancer

A study performed in the UK, reported in the British Journal Cancer (2010), showed that men who have a deleterious germ-line mutation in the breast cancer 2 (BRCA2) gene and who have prostate cancer do not survive as long as men with prostate cancer who are non-carriers. There have been earlier studies that have shown [...]

Possible Role of a BRCA1 Gene Loss in Metastatic Prostate Cancer Progression

Genetic counseling is common place in the world of breast cancer including the evaluation of the BRCA genes. Prostate and breast cancer increasingly been shown to have a relationship, perhaps all the down to the genetic level. Researchers are now understanding, that like in breast cancer, BRCA1 loss preexisting in small sub-populations of prostate cancer [...]

Unlocking the Genetic Code of Prostate Cancer for Better Treatments

Yesterdays Wall Street Journal publish a very important piece by Melinda Beck in their Health Journal (http://tinyurl.com/2dtrrll) . Everyone should go to the piece and read it. The piece, The Prostate Cancer Quandary, has received some play in the prostate community, but its real importance to us has not yet been recognized by our community [...]

Genetic Variant Associated With Aggressive Prostate Cancer

The American Association of Cancer Researchers (AACR) is in the midst of its annual scientific research meeting in Denver Colorado. As interesting prostate cancer specific information becomes available I will try and share the news. One of the biggest concerns we face in prostate cancer is in deciding when a cancer needs to be treated. [...]

Go to Top