A late-stage clinical trial designed to see if Xtandi in addition to Zytiga along with a steroid worked any better than either of these drugs separately (combining them v sequencing them) in men with advanced prostate cancer whose disease had worsened it was concluded that the combination was not superior to the individual drugs.

This means that in the case of these two drugs combining them and using them at the same time did not lead to improved health related outcomes then either of the drugs by themselves.