Olaparib – Effective for Certain Genetic Metastatic Prostate Cancer Strains

I have talked a lot about our need to take the next step in clinical care, understanding the best sequencing of our drugs. Since we have a number of new drugs to treat advanced prostate cancer we now need to better understand which drugs should be used in which men as well as their proper [...]

About the Important Genetic Prostate Cancer Study (UKGPCS) in the United Kingdom

Cancer is a genetic disease, so prostate cancer is a genetic problem. This statement might be the most important one we can make when trying to describe the current, overall situation we face as prostate cancer survivors! Many institutions have begun significant research studies trying to understand the actual genetic keys to prostate cancer. Prostate [...]

An Email & A Response About Prostate Cancer & Family History

I received an email from a lady from Australia that I though would be informative to share. It discusses genetic links and risk factors for hormonally related (including prostate) cancers: HER EMAIL TO ME Hi there :) I hope you don't mind me emailing you? I'm a lady from Australia and have 3 uncles with [...]

Researchers Find Consistent Epigenetic ‘Signatures’ In Prostate Cancer Patients’ Who Have Metastases

Scientists at the Johns Hopkins Kimmel Cancer Center found in a genome-wide analysis of 13 men with metastatic prostate cancer that there were consistent epigenetic "signatures" or “marks” across all metastatic tumors in each of the subject men. The discovery contradicts the current belief that epigenetic marks that sit on the nuclear DNA of cancer [...]

Genetic Predictors Of Fatigue For Men with Advanced Prostate Cancer Receiving Androgen Deprivation Therapy

The University of South Florida along with Moffitt Cancer Center has published a study in the October issue of Brain, Behavior, and Immunity which found that men with advanced prostate cancer who are on androgen deprivation therapy (ADT) are more likely to suffer from general fatigue if they also have single nucleotide polymorphisms in three [...]

A New Genetic Technique Predicts Prostate Cancer Relapse

According to a study published online May 9 in The American Journal of Pathology copy number variations (CNV) in both malignant and benign prostate tissue is predictive of prostate cancer relapse. The research performed at the University of Pittsburgh School of Medicine by Yan P. Yu, M.D. and colleagues evaluated whether CNV of the genomes [...]

Prostate Cancer and the Role of Genes As Prognosticators

We know that both a positive family history and racial background are among the strongest epidemiological risk factors for prostate cancer. It is also recognized that the role of candidate genetic markers to prostate cancer is more difficult to identify than the identification of other cancer susceptibility genes. Despite the localization of several susceptibility loci, [...]

A Lethal Form Of Prostate Cancer Attacked By A Targeted Drug Already In Clinical Trials

In today's issue of Cancer Discovery a group of international researchers report that an investigational drug had a dramatic response in animal models of neuroendocrine prostate cancer, a lethal form of the disease. The researchers pointed out that fewer than 2% of prostate tumors in men are initially diagnosed as neuroendocrine, but many of the [...]

The Role of BRCA2 Mutations in Aggressive Prostate Cancer

According to research published today in the British Journal of Cancer, routine testing for a faulty BRCA2 gene (Kote-Jarai Z et al, BRCA2 is a gene contributing to young onset prostate cancer: implications for genetic testing in prostate cancer patients British Journal of Cancer (2011) doi:10.1038/bjc.2011.383) in men under 65 years with prostate cancer could [...]

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