I compiled a list of trials that are activily recruiting men with hormone refractory prostate cancer (HRPC) who have also failed chemotherapy (taxotere). Being at this point in the disease process is by far the scariest time. We face the reality that there are no more approved treatments available to control the cancer.

Clinical trials are our best possible option at this time. Trials offer the opportunity to access cutting edge science. Trials are not without risks, so a very careful discussion with your doctors is vital prior to deciding to enter into any trial.

    Trials that are currently recruiting men with hormone refractory disease who have also failed chemotherapy:

Ixabepilone, Mitoxantrone, and Prednisone in Treating Patients With Metastatic Prostate Cancer That Did Not Respond to Hormone Therapy and Chemotherapy – NCT00331344

Use of Low Dose Ketoconazole in Prostate Cancer That Does Not Respond to Hormone Therapy and Prior Chemotherapy – : NCT00895310

Study of Patupilone in Prostate Cancer Patients Who Progress After Hormone Therapy and Docetaxel Chemotherapy – NCT00407251

Sorafenib to Overcome Resistance to Systemic Chemotherapy in Androgen-independent Prostate Cancer – NCT00414388

Safety and Efficacy Study of MDV3100 in Patients With Castration-Resistant Prostate Cancer Who Have Been Previously Treated With Docetaxel-based Chemotherapy- NCT00974311

Sunitinib Plus Prednisone In Patients With Metastatic Hormone-Refractory Prostate Cancer After Failure Of Docetaxel Chemotherapy (SUN 1120) – : NCT00676650

Study Using IMC-A12 or IMC-1121B Plus Mitoxantrone and Prednisone in Metastatic Androgen-Independent Prostate Cancer, Following Disease Progression on Docetaxel-Based Chemotherapy – NCT00683475

Mitoxantrone, Etoposide, and Vinorelbine As Second-Line Therapy in Treating Patients With Metastatic Prostate Cancer That Did Not Respond to Hormone Therapy- NCT00627354

PHA-739358 for Treatment of Hormone Refractory Prostate Cancer – NCT00766324

Satraplatin and Bevacizumab
in Treating Patients With Metastatic Prostate Cancer Previously Treated With Docetaxel – NCT00499694

Sorafenib, Pemetrexed, and Cisplatin in Treating Patients With Advanced Solid Tumors – NCT00703638

If you go to the web at:
http://www.clinicaltrials.gov and search for the trial number (the NCT number) you can read about the trial, as well as the inclusion and exclusion criteria.

Contact the trial director listed to get additional information as well as have any specific questions answered. Before deciding to join a trial you should discuss the trial with your doctor.

I urge you to consider entering into one of these trials, both for your sake and for the sake of those of us who will be facing this stage of disease progression in the future.

Those of us who are behind you in the timing of their cancer journey thank you for your willingness to explore new ground for our sake and the sake of our sons.

Joel T Nowak MA, MSW