David P. Wood, Jr., MD gave a presentation at the 9th International Prostate Forum (IPF) on October 8 – 10, 2009 in Izmir, Turkey on the Management the side effects of hormone therapy (ADT) when used to treat of prostate cancer.
Dr. Wood indicated that the three major side effects of ADT in the treatment of prostate cancer are the loss of libido, erectile dysfunction, and the onset of metabolic syndrome. Each of these side effects alone can be debilitating and so it is important for the treating doctor to give significant consideration to minimizing these side effects.
He estimated that hot flashes occur in 80% of men who are on ADT and that they do not abate with time if not treated. He indicated that progestational agents are effective in minimizing hot flashes.
Metabolic syndrome includes lipid abnormalities that lead to weight gain, hypertension, coronary artery disease, and fatigue. Since these abnormalities are difficult to prevent, he strongly recommended early treatment with appropriate medication is critical. Additionally, he advocated an institution of an aggressive exercise program which can prevent or slow down the progress of the metabolic syndrome and fatigue.
Skeletal related events (SRE) are caused by osteoporosis and bone metastases. Osteoporosis is common in men on ADT and continues over time even