On this blog I have tried to be minimally involved in writing about the PSA screening controversy, but I find it is getting hard to continue to avoid the issue. As I ate my breakfast this morning I was reading the New York Times and came upon the article “Quandary with Mammograms: Get a Screening, [...]
We have now been in this intense war against cancer for over 40 years and in many ways we still are losing. We have won some battles and some battles looked as though we were winning until that cancer enemy managed to sneak up behind us and have that last laugh. But, we have also [...]
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Medivation, Inc. (MDVN) has formally begun its phase III trial of the investigational drug MDV3100 with men who have advanced prostate cancer. The clinical trial known as AFFIRM will evaluate the novel androgen receptor antagonist, MDV3100, in men with castration-resistant prostate cancer who were previously treated with docetaxel-based chemotherapy. AFFIRM is a randomized, placebo-controlled, double-blind, [...]
One of the most heated debates in prostate cancer care is around the use of 5-reductase inhibitors (5ARI) like Dutasteride as a third component of a hormone blockade (ADT3). 5-ARIs block the conversion of testosterone to dihydrotestosterone (DHT). DHT is thought to be an extremely powerful “fuel” for the growth of prostate cancer. However, there [...]