Sipuleucel-T (Provenge) is FDA approved after a man becomes castrate resistant. In clinical trials it has shown that it extends life when compared to placebo. The use of Provenge has raised many questions, the two most common ones are why PSA and disease progression continues while receiving this treatment (see post at for an explanation) [...]
Researchers at the Harvard Medical School investigated the effect of androgen deprivation in a preclinical mouse model of stable high grade prostatic intraepithelial neoplasia induced by the loss of the PTEN tumor suppressor. They found that androgen deprivation treatment of these mice accelerated the progression to invasive disease. Shidong Jia, M.D., Ph.D. And associates found [...]
We all know that LHRH agonists are used for androgen deprivation therapy (ADT) cause a tremendous number of side effects, but it is not uncommon for our doctors to never discuss these potential side effects with us prior to starting therapy. Additionally, doctors neglect to offer alternative therapies that might accomplish the same results (like [...]
I just cannot remember where I put my keys. What is my home telephone number? What is his name, you know the guy I sit next to everyday in the office? Sound familiar, maybe because you are on hormone deprivation therapy (ADT) to treat your advanced prostate cancer. This can explain why your normally intact [...]
Having hot flashes because of hormone deprivation therapy (ADT)? All of us dealing with advanced prostate cancer will be on ADT, it is the usual first line of therapy and it will continue until we die. Men who elect to have radiation to treat prostate cancer as their primary treatment modality will often have some [...]