Non-metastatic Castrate Resistant prostate cancer patients take note. The Phase 3 PROSPER trial in patients with non-metastatic (M0) Castration-Resistant Prostate Cancer (CRPC) showed that the use of XTANDI® (enzalutamide) plus androgen deprivation therapy (ADT) significantly reduced the risk of developing metastases or death by 71 percent compared to ADT alone. It will be a [...]
Metastatic Prostate Cancer suffers have good news. Xofigo, also known as Radium-223 (Ra-223), is a treatment for patients with castration-resistant prostate cancer (CRPC) and symptomatic (you can feel them) bone metastases (mets). Early results of an international, open-label, phase 1/2 study (NCT01934790) showed that re-treating pts with Ra-223 was well tolerated with favorable effects on [...]
Anger hurts prostate cancer treatment. I feel angry and I'm not going to take my pills or show up for IMRT session. The thing about prostate cancer is that you’re not told what to do every step of the way or how to do it. Nothing is planned out for you, you just [...]
Five Estate Planning Documents to Have When You’re Battling an Illness Whether you’re young, old, healthy, or ill, estate planning should be a top priority. However, if you’re faced with a prostate cancer or have received some other unfavorable medical diagnosis, it’s especially critical that your legal affairs are in order and up to [...]
In the twenty years since I led Malecare’s first prostate cancer support group, this is the first time I have written an annual letter. Through the upturns and downturns, Malecare has always been a voice of optimism and powerful advocate for men diagnosed with prostate cancer. As we enter 2018, we are [...]
Searching for clinical trials is almost as hard as participating in clinical trials. clinical trial.gov is almost unusable. There are several businesses that have tried to make searching for clinical trials easier. Malecare is working with two of the very best. One, we can't tell you about in detail, since they are still in [...]
High serum levels of total and HDL cholesterol are associated with an elevated risk of advanced prostate cancer. Every 10mg/dl increase in serum total cholesterol adds a 5% increase to your odds of being diagnosed with advanced stage prostate cancer. Every 10mg/dl increase in HDL cholesterol increases your odds of having advanced stage prostate [...]
Men with non-metastatic castrate-resistant prostate cancer will soon know whether or not apalutamide is helpful. The USA based Food and Drug Administration has cut the review time from ten to six months. We might hear the FDA's ruling as early as April, 2018. Apalutamide (ARN-509) is an androgen receptor inhibitor and might prove to [...]
Exercise of any kind helps men at any stage of Prostate Cancer. Unfortunately, many advanced stage prostate cancer patients don't exercise enough. Advanced Prostate Cancer patients worry about bone pain more than other men. Androgen deprivation therapy, commonly called "hormone therapy," can cause bone problems. Metastases to bones can cause severe pain that many [...]
How cool is this? What if we can change how fast and far prostate cancer cells can metastasize by changing a single protein. The lead article in this months Oncotarget describes how prostate cancer moves in our bodies, and what we might be able to do to prevent metastatic cancer. Epithelial-to-mesenchymal transition (EMT) is [...]
