Perineural Invasion On Prostate Biopsy: Does It Mean that I Have Advanced Prostate Cancer?

The simple answer is NO, however it should change your treatment game plan. A member of one of my support groups who has been doing active surveillance for about 5 years recently reported that their current biopsy indicated that they now have perineural invasion (PNI). They did not understand what was the significance of [...]

From the 2013 2013 Genitourinary Cancers Symposium: High-Risk Prostate Cancer Treated with Pelvic Radiotherapy and 36 Versus 18 Months of Androgen Blockade

Men who are diagnosed with high risk prostate cancer, meaning they are more likely to develop advanced prostate cancer are usually treated with Radiotherapy (RT) and long term androgen blockade (AB). Currently, we do not know what is the optimal duration of AB. Looking at this problem, the researchers conducted a randomized study to compare [...]

Does ADT Cause Death from Myocardial Infarctions?

According to an article published in URO Today the belief that adjuvant androgen suppression therapy (AST) is associated with early deaths due to myocardial infarctions (MCIs) is not true. The belief that ASTs increases deaths from MCIs comes from the TROG 96.01 trial conclusions. Now there has been a retrospective, long term (ten year) meta-analysis [...]

Can Photo Dynamic Therapy Be On The Horizon?

Over the years there has been discussion about using Photo Dynamic Therapy to destroy internal tumors, including prostate cancer tumors. Until now it has only been a hope since there is no way to monitor the amount of light that is actually administered to an internal tumor. We currently use laser light in combination with [...]

Efficacy of a Modified Androgen Blockade in Prostate Cancer Patients with Biochemical Failure

How to best treat men with a prostate cancer PSA only recurrence (biochemical recurrence) still remains controversial. Hormone therapy (ADT) using a combination of a 5-alpha reductase inhibitor and an antiandrogen without conventional gonadal androgen suppression (where testosterone levels are not suppressed) may allow control of the prostate-specific antigen (PSA) with less morbidity. METHODS: In [...]


On Sunday at the AUA conference there was a poster (#159) titled ADJUVANT VS. SALVAGE RADIATION THERAPY FOLLOWING PROSTATECTOMY FOR LOCALLY ADVANCED PROSTATE CANCER: RESULTS FROM SEER-MEDICARE written by Keith J. Kowalczyk, etal. The researchers evaluated the optimal timing of external beam radiation (RT) after the completion of a radical prostatectomy (RP) as primary treatment [...]

From the AUA – Treated Positive Surgical Margins Impact Survival

Currently the American Urologic Association is holding their annual conference. Like the ASCO and AACR conferences there are many presentations and posters given that harkens the latest in research findings for general urological topics as well as for prostate cancer. I will be reporting on a number of these findings over the next period of [...]

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