E4 is a steroid that may become a treatment for advanced prostate cancer, both alone and fin combination with hormone therapy. Ellen Dutman, MSc, a clinical researcher, studied E4 as a treatment to lower testosterone. “An important advantage of E4 is expected to be the avoidance of the hypoestrogenic side effects that occur with other [...]
Androgen deprivation therapy (ADT, or, “hormone therapy”) may be linked to increased risk of having dementia. Researchers, Nead, Sinha and Nguyen reviewed nine studies by other researchers. Seven of those studies reported an adjusted effect estimate for dementia risk. That means that a majority of today’s evidence based research says that ADT and dementia probably [...]
Quality of Death. A new term we are introducing to the prostate cancer discussion. Will I die in pain, agony or in some semblance of peace? Do I want to be stupefied by opioids during my last days, hours and minutes? Do I want to enter a coma like state? Would I like to [...]
Here is the latest challenge to PSA test usefulness for Prostate Cancer screening in the USA. Malecare feels you should be empowered to participate in this national health policy issue. The U.S. Preventive Services Task Force released a new guideline, determining that the potential benefits and harms of prostate-specific antigen (PSA)-based screening in men [...]
Yervoy (ipilimumab) alone doesn’t help treat advanced prostate cancer patients. Yervoy activates the immune system by going after the CTLA-4 protein receptor that slows immune-system activity. But prostate cancer responds to Yervoy by increasing two other immune checkpoint molecules, PD-L1 and VISTA. And both send a don’t-eat-me signal to immune cells. That reaction is why Yerboy, by [...]