A New Steroid for Treating Advanced Prostate Cancer

//A New Steroid for Treating Advanced Prostate Cancer

E4 is a steroid that may become a treatment for advanced prostate cancer, both alone and fin combination with hormone therapy. Ellen Dutman, MSc, a clinical researcher, studied E4 as a treatment to lower testosterone.

“An important advantage of E4 is expected to be the avoidance of the hypoestrogenic side effects that occur with other types of testosterone-suppressing hormone therapy, including hot flushes and sweating, arthralgia, mood, sleep and cognition disturbances, and bone loss and fractures,” said Ms Dutman.

In Ms. Dutman’s study, E4 doses were well tolerated, with no change in body weight or safety parameters, but libido decreased and nipple tenderness was reported.

“E4 treatment may not be as expensive as recently developed new prostate cancer therapies,” said Ms Dutman. “We expect that in the future, patients with advanced prostate cancer will have the opportunity to choose to be treated with E4, especially in combination with their current therapy.”


  1. Dutman AE, Zimmerman Y, Bennink HJTC. The effects of the human fetal estrogen estetrol (E4) in healthy men to estimate its potential use for the treatment of prostate cancer. Poster presented at: ENDO 2017, the annual scientific meeting of the Endocrine Society; April 1-4, 2017; Orlando, FL. Abstract SAT 171.
By | 2017-04-18T17:30:37+00:00 April 18th, 2017|Advanced Prostate Cancer|2 Comments

About the Author:

Malecare is the world’s leading men’s cancer support and advocacy nonprofit organization.


  1. Tom September 18, 2017 at 10:21 am

    I’ve been diagnosed with Stage 4 prostate cancer and has spread to my bones. There is so much information that contradicts each other you don’t know what to believe. I’m told I could live for years but then read I have only a 1% chance of living more than a year because of my age (70). Is there a site where I can get accurate information I am undergoing chemo therapy but not radiation therapy.

  2. Malecare October 3, 2017 at 11:22 am

    Hi Tom I suggest joining the advanced prostate cancer community at https://healthunlocked.com/advanced-prostate-cancer

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