It has always been assumed that Ketoconazole, when used for the treatment of men with metastatic castration resistant prostate cancer (mCRPC), would not be as potent as abiraterone (Zytiga), but there has never been any head to head comparison to demonstrate this assumption! Ketoconazole is a less potent inhibitor of the CYP-17 enzyme, the mode [...]
There is some really good news for those of us who live in areas where The National Institute for Health and Care Excellence (NICE) recommends drug approvals. NICE has issued a final draft guidance recommending that men with hormone-relapsed prostate cancer (castrate resistant) that has metastasized and has been treated with docetaxel (chemotherapy) should be [...]
There are occasional conversations about the possibility of looking at a man’s fingers and predicting the aggressiveness of their prostate cancer. Is this real science or is this voodoo science? This might actually be real science! During gestation a male fetus’s development of the prostate gland is dependent on a functional androgen receptor and the [...]
On this day eight years ago I made my first post on fatherdad.com. That was the first ever post by a black "daddy blogger." I searched high and low for one before I determined that I was it. I think that post is a hilariously bad and somewhat profound (and very much unnoticed) internet milestone. [...]
It comes without any great surprise, but earlier in the month the FDA announced they were giving the application from Astellas and Medivation for a priority review to extend the indication (FDA approved use) for Xtandi (enzalutamide) capsules for the treatment of men with metastatic castration-resistant prostate cancer (mCRPC) who have not received chemotherapy. The [...]