An interesting, but it makes sense type of study, was discussed about the relationship between high levels of triglycerides (TG) and the development of prostate cancer, including more aggresive prostate cancer. It of course follows suite that prostate cancer diagnosed with higher gleason scores (more aggressive) leads to more advanced prostate cancer.
This study which is a Aetiology Study (individual cohort) provides a Level of Evidence of 2b.
The study examined men over the age of 60 years who had highlevels of TG, specifically to examine the relationship between serum triglyceride (TG) levels and the incidence and characteristics of prostate cancer detected on biopsy.
The researchers evaluated data taken from consecutive men who underwent a prostatic biopsy. They analysed data including age, total serum prostate-specific antigen (PSA) level, prostatic volume, body mass index (BMI), TG levels, and the use of cholesterol-lowering medications.
They used a multivariate analysis on the 905 men in the study, including 528 (58.3%) with positive biopsy findings, using 150?mg/dL as the threshold point of TG levels.
– The analysis yielded an adjusted odds ratio (OR) reflecting the association of higher TG levels with prostate cancer diagnosis of 1.66 (95% confidence interval (CI) 1.21-2.29, P?=?0.002).
-? Pearson correlation coefficient analysis including age, PSA level, prostatic volume, BMI and TG, showed TG level significantly correlated with BMI (r?=?0.185, P?0.001).-? In the analysis by age intervals (?59, 60-69, and ?70 years), the association between high TG levels and positive biopsy findings was enhanced in the age groups 60-69 and ?70 years (OR 2.10, 95% CI 1.31-3.37, P?=?0.002 and OR 1.91, 95% CI 1.03-3.53, P?=?0.039, respectively), but not in the group aged ?59 years. •?- In men aged ?60 years, high TG levels were statistically significantly associated with a Gleason score of ?8.The study concludes that:•? High TG levels correlated well with a higher incidence of prostate cancer, especially in patients aged ?60 years.•? High TG levels were also associated with a Gleason score of ?8 in this age group. •?The study suggest that men over the age of 60 years with high TG levels may be more vulnerable to the development of prostate cancer with an aggressive biology. The significant implications are particulaly important for men in the age bracket with high TG levels who might otherwise consider active survalliance.BJU Int. 2011 Aug 4. doi: 10.1111/j.1464-410X.2011.10358.x. [Epub ahead of print Hayashi N, Matsushima M, Yamamoto T, Sasaki H, Takahashi H, Egawa S. Source Department of Urology, Division of Clinical Research and DevelopmentDepartment of Pathology, Jikei University School of Medicine, Minato-ku, Tokyo, Japan.PMID: 21812901 [PubMed - as supplied by publisher]Joel TNowak, M.A., M.S.W.