Can Tamoxifen Manage Breast Events Induced by Non-Steroidal Antiandrogens in Men with Advanced Prostate Cancer?

Many of us who are fighting advanced prostate cancer struggle with the perplexing side effects of non-steroidal antiandrogens (like Casodex). These side effects include gynecomastia (breast enlargement) and breast pain. In most cases as we use these drugs our breasts grow, become very sensitive and/or painful. In my case my breasts have grown to the [...]

New Phase 2 Trials For MDV3100 Begins & Another To Start Soon – On The Horizon

It was announced today that the first patient in the TERRAIN study received their first dose in the Phase 2 trial of the investigational drug MDV3100 . MDV3100 is a triple-acting oral androgen receptor antagonist that I have writing about as a drug “On The Horizon”. Triple-acting means that it blocks testosterone binding to the [...]

The Name of The Game Is Life Extension

Advanced prostate cancer will progress and most of us will face a time when Androgen Deprivation Therapy (ADT) stops working. Most men on ADT take a LHRH agonist, which turns off the production of testosterone (i.e. Lupron) along with a non-steroidal anti-androgen (i.e. Casodex) that prevents the small amount of testosterone that continues to be [...]