According to a recent presentation by Mitchell C. Benson, MD*, at the 32nd Winter Urologic Forum – State-of-the-Art in Urology – January 25-29, 2008 – Vail, Colorado, USA most men who have failed a local, primary therapy and then experience a rising PSA will find that their follow-up therapy will most probably consist of anti-androgen hormonal therapy (ADT). As we all know the timing of the commencement of the ADT and how to utilize it (continuous or intermittent) remains very controversial.
PSA doubling time can be used to determine when, and in some cases if, androgen deprivation therapy should be prescribed. The Table below illustrates the utility of PSA Doubling time.
PSA Doubling Time………..Time to Metastases……………………Survival
……(Months)………………………..(Years)…………………………………(Years)
………..3…………………………………2…………………………………………….6
………..6…………………………………4…………………………………………….8
………..9…………………………………6……………&#