Phase III Clinical Trial for OGX_011 – A Treatment for Failed Chemotherapy

At the last ASCO Annual Meeting Saad et al. presented a report about a Phase II trial of custirsen (OGX-011) + docetaxel + prednisone vs. custirsen + mitoxantrone + prednisone in metastatic hormone-refractory prostate cancer. The subjects in the study had experienced relapses of cancer progression within 6 months of treatment with first-line docetaxel therapy. [...]

Why ADT Ultimately Fails

Hair on a man's head offers clues about versatility of a molecule central to Advanced Prostate Cancer. Once again, those of us fighting advanced and recurrent prostate cancer are confronted with contradictory and confusing information. The usual first line treatment for advanced prostate cancer is hormone therapy (ADT). We all know that ADT is short [...]

Caution, Avoid Grapefruit And Other Juices When Taking Certain Drugs

We all know, or at have heard, that drinking grapefruit juice can increase the absorption of certain oral drugs. The result of the increased levels of absorption is the possibility that normal doses of drugs become toxic overdoses. At the 236th National Meeting of the American Chemical Society there was a presentation that provided new [...]

New York Times – In Cancer Therapy, There Is a Time to Treat and a Time to Let Go

Today’s New York Times had an article written by Jane Brody that discusses the painful issues surrounding the decision to stop treatment, and its negative side effects, and let a cancer survivor live their last weeks in relative peace. This is always a difficult decision as many of us wish to hold on to life, [...]

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