Understanding What is Neuroendocrine Differentiation in Prostate Cancer

Understanding a little about the prostate gland and its biology is not only interesting, but it allows us to ask some important questions that can positively inform our treatment decisions and eventually the outcomes. On the other hand, it also can add to the confusion we all face in making the best clinical decisions. Like [...]

Initial Gleason Score Does Not Impact Abiraterone (Zytiga) Benefit in Prostate Cancer

Clinical trials have shown that there is an overall survival and radiographic progression-free survival benefit derived from abiraterone acetate (Zytiga) in the treatment of men with metastatic castration resistant prostate cancer (mCRPC). A new retrospective study published online, ahead of print, shows this trend is true regardless of a man's Gleason score at diagnosis, despite [...]

Why A Diet Heavy in Fruits and Vegetables Might Help Men With Prostate Cancer

Many people consider food diet important in both prostate cancer prevention and in controlling its progression. Dietary derived agents, such as the flavonoids derived from fruits and vegetables should be of particular interest for prostate cancer survivors, as they seem to offer both chemo-prevention and an antioxidant effect along with a favorable safety and side-effect [...]

Showing an Association Between RECIST Changes and Survival in Men with Castrate Resistant Prostate Cancer Receiving Chemotherapy

The Response Evaluation Criteria In Solid Tumors (RECIST) was first published in 2000 and then updated in 2009. RECIST is a set of published rules that attempt to define when cancer tumors, including prostate cancer tumors, improve ("respond"), stay the same ("stabilize"), or worsen ("progress") during treatment. This criteria has become very important as the majority [...]

Understanding the Result of Neuroendocrine Differentiation in Prostate Cancer

Understanding a little about the prostate gland and its biology is not only interesting, but it allows us to ask some important questions that can be very specific to our prostate cancer treatment decisions and our eventual outcomes from these decisions. It also can simply add to the confusion we all face in making the [...]

The Role of Sleep Disturbance On Prostate Cancer Risk and Progression

I stumbled upon a fascinating piece of research from Iceland that looked at the role of Circadian Disruption in Prostate Cancer Development. Knowing my own very poor sleeping patterns and having heard many other men with advanced prostate cancer complaining about very similar experiences it peaked my interest. The researchers pointed out that there have [...]

Is Provenge for you?

Provenge, despite its demonstrated survival advantage, continues to be knocked as a viable treatment for men with castrate-resistant prostate cancer. What is Provenge? Provenge is immunotherapy for men with metastatic castrate-resistant prostate cancer. In other words, Provenge might help men live longer after their cancer has spread outside of the prostate and are no [...]

On Hormone Therapy – To Statin Or Not, That Is The Question

JAMA Oncology has published a new study that suggests that adding a statin drug at the initiation of hormone therapy (ADT) to the treatment protocol for a man with progressive, hormone-sensitive prostate cancer may significantly impact their actual time to disease progression (TTP). Historically, we know Statin use has been associated with improved prostate cancer [...]

Is Delaying The Start of ADT Safe for Prostate Cancer Patients?

A recently previewed (prior to the upcoming ASCO Annual Meeting) of a large study shows that men with prostate cancer who had a PSA-based relapse (Biochemical Recurrence) could delay starting androgen deprivation therapy (ADT) until they started experiencing symptoms from the cancer. They found that this delay would not affect the men’s long-term survival. The [...]

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