Chemo Therapy Failure - malecare.org

On the Horizon- Patupilone in Patients with Metastatic Castration-Resistant Prostate Cancer who have Progressed after Docetaxel – A Phase II Study

Once we have failed docetaxel therapy (chemo therapy) we have very few options available to control advanced prostate cancer. There is a recnt report about a clinical trial using a new potential drug, Patupilone. Patupilone has shown some evidence that it exhibits a limited positive effect in the pre-clinical setting in taxane resistant models of [...]

By Malecare|2017-10-19T10:54:41-04:00August 14th, 2009|Advanced Prostate Cancer, Chemo Therapy, Chemo Therapy Failure, Clinical Trials, Clinical Trials, Drugs & Treatments, On The Horizon, Uncategorized, Understanding APC|0 Comments

Mitoxantrone Plus Prednisone – A Possible Fallback After Taxotere Failure

Men with metastatic hormone-refractory prostate cancer (mHRPC) who become docetaxel-refractory (no longer responsive to docetaxel therapy have no approved second line chemotherapy available. One could say that they have reached the proverbial brick wall. Where to go and what to do is not at all clear. Most of us do not want to just roll [...]

By Malecare|2017-10-19T10:54:46-04:00July 20th, 2009|Advanced Prostate Cancer, Chemo Therapy, Chemo Therapy Failure, Drugs & Treatments, End-Of-Life, How We Live, Uncategorized, Understanding APC|0 Comments

A Clinical Trial : Ixabepilone, Mitoxantrone, and Prednisone in Treating Patients with Metastatic Prostate Cancer That Did Not Respond to Hormone Therapy and Chemotherapy

I was recently reviewing current clinical trials and came across this one for men who have failed chemotherapy, what many of us view as the final treatment for advanced prostate cancer. It provides a potential opportunity to combine two different therapy agents (one old, mitoxantrone; one relatively new, ixabepilone). Both of these chemicals are known [...]

By Malecare|2020-02-04T10:11:12-05:00February 2nd, 2009|Advanced Prostate Cancer, Chemo Therapy, Chemo Therapy Failure, Clinical Trials, Clinical Trials, Uncategorized|7 Comments

An NCI Clinical Trail After Chemotherapy Has Failed

What do advanced prostate cancer survivors do once we fail chemotherapy? At this time there are no FDA approved next steps other than to take some time off and pray that restarting chemotherapy will again help us. To put in another way, we wait to die. There is a huge need to find additional strategies [...]

By Malecare|2020-02-04T10:39:41-05:00January 8th, 2009|Advanced Prostate Cancer, Chemo Therapy, Chemo Therapy Failure, Clinical Trials, Clinical Trials, Uncategorized|0 Comments

Estramustine Plus Docetaxel After A Vacation as Second-Line Therapy in Patients with Hormone-Refractory Prostate Cancer Resistant to Docetaxel

What is left for us once we become resistant to docetaxel (DOC) plus prednisone, which is the last FDA approved, standard of care treatment available for advanced hormone refractory prostate cancer? There has been some studies that indicate after a “vacation period” similar to what many of us do with a first line hormone blockade, [...]

By Malecare|2017-10-19T10:56:33-04:00December 8th, 2008|Advanced Prostate Cancer, Chemo Therapy, Chemo Therapy Failure, Drugs & Treatments, Uncategorized, Understanding APC|0 Comments