On the Horizon – Targeting Bones in the Treatment of Advanced Prostate Cancer

Osteoblasts and osteoclasts are the process that the body uses to breakdown old bone and then to rebuild it with new bone. c-Met is a tyrosine kinase expressed by osteoblasts and osteoclasts, and overexpressed by prostate cancer cells. This over expression leads to the eventual development of bone metastases. The experimental treatment known as Cabozantinib [...]

Important – Read the Prescribing Information that Comes with Your Medications

The following is a post from Chuck Maack on the Advanced Prostate Cancer Internet support group: “It came to mind wondering how many patients and/or their caregivers prescribed Zytiga/abiraterone acetate have ever taken the important time to read all the details regarding the effects that may be experienced by patients and whether or not they [...]

How Reliable Are On-line Medical Resources When Discussing Hormone Therapy (ADT)?

My friend and colleague, Richard Wassersug published an article on April 4, 2013 on the on-line service, Uro-Today.com, about the lack of reliability on internet sites when they discuss hormone therapy. Dr. Wassersug is a Professor in the Department of Anatomy and Neurobiology at Dalhousie University, Canada. His research interests include the Psychosocial impact of [...]

Chemotherapy Every Two Weeks Might Be Superior to the Standard Every Three Week Schedule Currently Used

Chemotherapy with Docetaxel is usually given on a once every three (3) week schedule of 75 mg/m2 administered intravenously + prednisolone (10 mg/day p.o.) for men with advanced prostate cancer. In the cases when the side effects are too difficult for a man to tolerate, the dose is often reduced to 50 mg/m2 administered intravenously [...]

The Literature on Androgen Deprivation Therapy (ADT) Has a Systemic Bias Causing Poor Clinical Practice In Men with Advanced Prostate Cancer

We all know that LHRH agonists are used for androgen deprivation therapy (ADT) cause a tremendous number of side effects, but it is not uncommon for our doctors to never discuss these potential side effects with us prior to starting therapy. Additionally, doctors neglect to offer alternative therapies that might accomplish the same results (like [...]

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