There’s a new Phase 3 clinical trial for an oral medication, taken one time per day, that will reduce testosterone for advanced prostate cancer.
Myovant Sciences is testing their new drug, called Relugolix in a trial called, HERO. Relugolix lowers testosterone by inhibiting pituitary release of luteinizing hormone and follicle-stimulating hormone.
Todays testosterone reducing therapies require injections and the most commonly used such as Lupron start off by raising testosterone and causing a clinical flare of symptoms. Relugolix decreases testosterone within days of initiation and might enable quick testosterone recovery when treatment ends. That would be super for men thinking abou intermittent therapy.
Interesting. I have been on Zytiga for 18 months, but my T has slowly risen from an low of <0.065 to 0.185 and, at some point, I will need to try something different than my current Lupron/Zytiga stategy. My recent CT still shows no sign of my previous omental nodes. I started 7 years ago with a Gleason 10 prostate followed by IMRT, Implant and Cryotherapy. The LHRH antagonist sounds like it might be the best option.