Understanding Advanced Prostate Cancer

/Understanding Advanced Prostate Cancer

Flawed Study Shows A Sharp Rise in Advanced Prostate Cancer

Yesterday’s post described research performed at Northwestern University that found a sharp increase in the number of men diagnosed with advanced aggressive prostate cancer between 2004 and 2013. The research interpretation raised the possibility that the United States Preventive Task Force (USPTF) decision to recommend against the use of the PSA test for prostate cancer [...]

Reporting A Concerning Increase In The Number Of Men Diagnosed With Advanced Prostate Cancer

According to information from a published report from the Tuesday, July 19, 2016 edition of HealthDay News, there has been an explosion of new cases of advanced prostate cancer in the United States. They reported on a study using data on nearly 800,000 men listed in the National Cancer Data Base who had been diagnosed [...]

Abiraterone And Enzalutamide Effect Cognitive Impairment and Depression in Men With Metastatic Castration-Resistant Prostate Cancer (mCRPC)

Speaking with men who have taken abiraterone (Zytiga, ABI) and enzalutamide (Xtandi, ENZA), at Malecare we sometimes hear reports of both cognitive and mood changes brought on by these two drugs. Evaluating these two problematic side effects researchers have confirmed our experience, both of these drugs can cause these symptoms and that more men reported [...]

A Prospective Evaluation Of The Health Related Quality of Life In Men Receiving Primary and Secondary Treatment for Prostate Cancer

Men with both high risk and intermediate risk prostate cancer will receive primary treatment and many also receive a second line of treatment. In a study that was designed to assess the impact of receiving both first and second line treatment on a man’s Health Related Quality of Life (HRQoL), researchers determined that men who [...]

Be Cautious Taking Megace To Treat Hormone Therapy Hot Flashes

When taking hormone therapy (ADT) each of us experiences different side effects and each of us experiences them differently.  Anyone experiencing hot flashes, probably the most commonly reported side effect of ADT during hormone therapy (ADT) knows how difficult, embarrassing and uncomfortable they can become as you go through your life. Some men, who find [...]

Genetic Biomarker Predicts Peripheral Neuropathy Associated With Docetaxel Chemotherapy For Prostate Cancer

According to researchers at the H. Lee Moffitt Cancer Center & Research Institute, men with a mutation in their VAC14 gene are more susceptible to Docetaxil chemotherapy induced neuropathy and nerve pain. This debilitating side effect results from damage to the peripheral nerves and is felt by the man as weakness, numbness and pain most [...]

An Independent Prognostic Tool For Men With Metastatic Castrate Resistant Prostate Cancer Taking The Newer Drugs

We have a number of newer hormone pathway drugs now available to treat men with metastatic castrate resistant prostate cancer (mCRPC). Researchers have shown that prostate specific antigen (PSA) response can be used as a pharmaco-dynamic end-point that may help identify men with early resistance to these new drugs. They found that there is clinical [...]

Early Hormone Therapy In Men With A Rising PSA Live Longer Then Men Who Delay Therapy – A Phase 3 Trial

The standard of care is to offer androgen deprivation therapy (ADT) to men with prostate cancer who have a rising prostate specific antigen (PSA) after an attempt to cure their cancer with primary therapy that has failed (PSA relapse) or in men who are considered not suitable for curative treatment. The question is what is [...]

Short Term Androgen Therapy Might Be Better For More Aggressive Gleason Grade Prostate Cancer

In a recently published commentary about the optimal type of multi-modal hormone therapy for Gleason grade 4 and 5 prostate cancer the author addressed the discordance between results of several randomized trials evaluating survival benefit of continuous androgen deprivation therapy in men with high-risk disease. The study found that after combining data from multiple trials, [...]

Understanding Prostate Cancer Clinical Trials – Types and Stages

The decision to enroll in a clinical trial should involve a discussion between the person with prostate cancer and that individual’s physician. Your participation should depend on many factors, including your motivation for enrolling in a trial, the stage of your prostate cancer, and the trials available and its phase. When you decide to enroll in a clinical [...]