C-Reactive Protein as Adverse Prognostic Marker for Men with Castration-Resistant Prostate Cancer

A confirmatory study evaluating the prognostic value of C-reactive protein (CRP) levels in men with castrate-resistant prostate cancer (CRPC) was presented at the 2009 American Society of Clinical Oncology (ASCO) conference in Orlando Florida. Historically, CRP has been associated with adverse outcomes in men with CRPC treated with docetaxel. This study, presented by R. Prins, [...]

Factors Pointing to the Development of Metastatic Prostate Cancer

It is inevitable; most men with prostate cancer, who require treatment with androgen deprivation therapy (ADT), will eventually become resistance to treatment leading to the development of metastatic disease. Men who develop metastatic castrate-resistant disease have a very poor prognosis. Historically, their overall survival is estimated only to be 24 to 36 months. A study [...]

Carboplatin-Taxane Combinations in the Management of Castration-resistant Prostate Cancer

The use of Docetaxel (chemotherapy) extends survival time in men with castration-resistant prostate cancer (CRPC). Many researchers believe that platinum compounds, particularly Carboplatin, when added to docetaxel (taxane-based chemotherapy) can further extend survival times. A study at the Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA. Investigated the efficacy [...]

Stromal Biomarker Appears to Predict Advanced Prostate Cancer

The absence of a stromal protein called caveolin-1 appears to be a marker for advanced prostate cancer and for metastasis, researchers from the Kimmel Cancer Center at Jefferson and Harvard Medical School reported in "Cell Cycle." Caveolin-1 has already been shown to be a good biomarker serving as a prognostic factor for breast cancer. The [...]

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