Secondary Hormonal Ablation in Hormone-Independent Prostate Cancer

So how long does it usually take for men undergoing hormone therapy (ADT) to progress from being hormone dependent to hormone independent? Clearly, we should always remember that this is a very individual, case-by-case time. However, there was a recent time analysis published in the February 2009 edition of Urology. These researchers found that after [...]

Does Androgen-Deprivation Therapy Provide a Survival Benefit? A Look at Survival Outcomes in Men Receiving ADT as Primary or Salvage Treatment for Localized or Advanced Prostate Cancer- Conclusions from a 20-Year Single-Center Experience

The Department of Urology, University of Tennessee Health Science Center, Memphis, TN, performed a retrospective study designed to evaluate the overall survival (OS) and disease-specific survival (DSS) in men receiving primary androgen-deprivation therapy (PADT) or salvage medical ADT (SADT) for prostate cancer. The study included men who were diagnosed and treated with ADT between July [...]

Cognitive Impairment From Luteinizing Hormone-Releasing Hormone Agonists for Prostate Cancer

When I was on an active hormone blockade (ADT2) I suffered extensively from many of the usually reported morbidity issues (negative side effects). One of the side effects I dealt with was significant cognitive impairment. I live in New York City, was born in the city and have spent most of my life in the [...]

ADT Increases Risk Factors for Diabetes, Fractures and Cardiovascular Mortality

Not a very big surprise but androgen-deprivation therapy (ADT) substantially increases the risk for cardiovascular and bone-related problems, as well as for diabetes, according to a review of the medical literature published online April 27 in the journal Cancer. At the University of Texas Health Science Center in Houston, Lockwood G. Taylor wrote a review [...]

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