Prostate Cancer and the Role of Genes As Prognosticators

We know that both a positive family history and racial background are among the strongest epidemiological risk factors for prostate cancer. It is also recognized that the role of candidate genetic markers to prostate cancer is more difficult to identify than the identification of other cancer susceptibility genes. Despite the localization of several susceptibility loci, [...]

Early Versus Delayed Use of Hormone Therapy- An Analysis For Men with Advanced Prostate Cancer

Initially, when first used by Huggins and Hodges hormone therapy (ADT) was recommended to be used early on in prostate cancer disease progression. Eventually, the Veterans Administration Cooperative Urology Research Group (VACURG) studies reversed this early recommendation. After this study ADT was usually deferred until symptomatic progression. It was believed that ADT caused an alteration [...]

Congressional Men’s Health Caucus Starts The Prostate Cancer Task Force – Ask Your Member of Congress To Sign The Dear Colleague Letter

Several years ago we worked with members of Congress to promote a Congressional Men’s Health Caucus and we were successful. The Caucus has been active through the years on various health issues affecting men and boys. The current leaders are Reps. Runyan and Shuler. Now, we are ready for the next step, the Congressional Men’s [...]

Risk Of Suicide In Men With Prostate Cancer Could Be Lowered

The statistics are shocking; men with prostate cancer are twice as likely to commit suicide! Researchers at the Sahlgrenska Academy at the University of Gothenburg, Sweden have devised a method to try and cut back on the number of suicides. Their method involves putting intrusive thoughts into words with the goal of reducing the risks. [...]

Combined Androgen Deprivation Therapy and Radiation Therapy for Locally Advanced Prostate Cancer:Positive Results

A group of researchers just reported positive results of a phase 3 trial showing that the addition of radiation therapy (RT) improves overall survival in men with locally advanced prostate cancer (T3 & T4) to androgen deprivation therapy (ADT) alone. The researchers used a sample of 1,057 men with locally advanced (T3 or T4) prostate [...]

Androgen Receptor Genes Have An Opposite Effect In Prostate & Breast Cancers

A study at The Cleveland Clinic has discovered that a gene – known as an androgen receptor (AR) is present in both breast and prostate cancers, but the gene has opposite effects on these diseases. The AR gene promotes prostate cancer when the gene is “turned on,” but in breast cancer the AR gene promotes [...]

The Role of BRCA2 Mutations in Aggressive Prostate Cancer

According to research published today in the British Journal of Cancer, routine testing for a faulty BRCA2 gene (Kote-Jarai Z et al, BRCA2 is a gene contributing to young onset prostate cancer: implications for genetic testing in prostate cancer patients British Journal of Cancer (2011) doi:10.1038/bjc.2011.383) in men under 65 years with prostate cancer could [...]

Alpha Blockers Linked to Prostate Cancer Relapse

A retrospective study has just been published that shows that the risk of experiencing a biochemical recurrence (PSA recurrence) after radical prostatectomy to treat prostate cancer increased significantly in men who received alpha blockers for lower urinary tract symptoms (LUTS) after surgery. When compared to men who did not receive alpha blockers, those who did [...]

HOUSE, SENATE AT ODDS OVER NIH, NCI FUNDING

OK, I give up. I clearly don’t understand American politics! A new House proposal puts research funding at center of broader FY2012 budget debate, but not the way I would have predicted. In a surprise move the Republican House leaders released a draft proposal that would increase fiscal year 2012 funding for the National Institutes [...]

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