Clinical Trials | malecare.org

Phase III Trial Comparing Orteronel (TAK-700) Plus Prednisone Against Placebo Plus Prednisone Fails

Reporting both negative clinical trial results is as important as reporting positive results. However, pharmaceutical companies often bury negative results. Fortunately (actually unfortunately because there were negative results) a Phase III, randomized, double-blind, multicenter trial comparing orteronel (TAK-700) plus prednisone with placebo plus prednisone in men with metastatic castration-resistant prostate cancer (mCRPC) that has progressed [...]

By Malecare|2020-02-04T11:36:51-05:00April 3rd, 2015|Advanced Prostate Cancer, Clinical Trials, Clinical Trials, TAK700, Uncategorized|0 Comments

Controversy at ASCO GU: Conflicting Randomized Trials on Docetaxel Plus ADT for Hormone Sensitive Metastatic Prostate Cancer *

Last year after the ASCO meeting in Chicago I declared that there was one particular presentation of the CHAARTED trial that would be a game changer for the treatment of newly diagnosed men with very significant prostate cancer. The game changer was that men diagnosed with significant disease and who were still ADT naive (not [...]

By Malecare|2020-02-04T10:39:13-05:00April 1st, 2015|Advanced Prostate Cancer, ASCO, Chemo Therapy, Clinical Trials, Clinical Trials, Drugs & Treatments, Hormone Therapy, taxotere, Uncategorized, Understanding APC|0 Comments

Detecting Prostate Cancer Cells in Blood Can Give An Early Warning of Treatment Failure and Shorten Clinical Trials

There is more evidence that the blood test used to count the number of cells circulating in the blood and shed from prostate tumors (circulating tumor cells or CTCs) can indicate whether a treatment is working or not working. A major new study showed that the number of these circulating tumor cells in the blood [...]

By Malecare|2017-10-19T10:47:29-04:00March 27th, 2015|Advanced Prostate Cancer, Clinical Trials, Clinical Trials, CTCs, General Information, On The Horizon, Uncategorized, Understanding APC, Zytiga|0 Comments

A Real Role for Immunotherapy in the Treatment of Advanced Prostate Cancer

Immunotherapy has a major and expanding role in the treatment of cancer, including advanced prostate cancer. Over time there have been a number of naysayers as the immunotherapy Provenge has played the role whipping boy by critics. The common criticism leveled at Provenge can be summed up simply, “It doesn’t work.” The plain truth is [...]

By Malecare|2017-10-19T10:47:29-04:00March 26th, 2015|Advanced Prostate Cancer, ASCO, Clinical Trials, Clinical Trials, Drugs & Treatments, immunotherapy, ipilimumab, Prostvac, Uncategorized, vaccines, Yervoy|3 Comments

Coming Back to Continue the Blog and New Data Disclosed on Enzalutamide at the Plenary Session at the 2015 European Association of Urology Congress

Before I get into the meat of today’s post about enzalutamide, I want to briefly make some personal comments about my absence from this blog. As I had mentioned I have been diagnosed with a fifth primary cancer, appendiceal cancer. It is a rare cancer, which required my having to remove my appendix, a piece [...]

By Malecare|2017-10-19T10:47:29-04:00March 24th, 2015|Advanced Prostate Cancer, Casodex, Clinical Trials, Clinical Trials, Drugs & Treatments, enzalutamide, Hormone Therapy, Uncategorized, Xtandi|0 Comments