One of the significant secondary side effects resulting from of our advanced prostate cancer treatments can be blood clots. Blood clots are potentially dangerous as they can lead to heart attacks, strokes and death. Warfarin is one of the drugs commonly prescribed to prevent these dangerous blood clots from ever forming. However, dosing of Warfarin [...]
A graduate student, Patrica Ames, has requested that I announce her request for subjects to participate in a study she is performing about clinical trial participants. Here it is: Invitation: Hello. I am reposting this request for volunteers to help me with my PhD research. I am very grateful that some have already spent the [...]
The occasionally discussed, but not often used, alternative hormone therapy, transdermal estrogen might be ready to soon move on to a phase III trial. A poster presentation of a phase II trial showed that transdermal estrogen patches drove down testosterone and PSA levels to a similar extent as an LHRH analog. The poster presentation was [...]
There has been some positive news coming out of the ASCO conference in Florida this past week. One of the most significant pieces of positive news deals with the results of a phase I-II trial of the drug known as MDV3100. Basically, more than half of subjects in the study with castration-resistant prostate cancer responded [...]
Why should I participate in a clinical trial? If I participate in a trial I take a risk and probably the trial will fail to prove that there is a better drug or treatment, so why should I put myself at risk with no chance of anyone getting any benefit? This is an excellent question [...]
Marshall Edwards, Inc. (NASDAQ: MSHL) is planning to release preliminary results from a Phase II clinical trial of oral phenoxodiol in patients with early and advanced stage prostate cancer. The results will be presented by the Yale researchers, who were responsible for the study, at the ASCO Genitourinary Cancers Symposium in Orlando, Florida; February 26-28, [...]
There is nothing more frustration that the current methods used by the FDA to approve drugs. The theory is great, but how it gets translated into our real world is killer, I mean a literal killer of men. The FDA wants assurances that before they approve a drug that it really works, or shows efficacy. [...]
An announcement from Market Watch claims that Cougar Biotechnology has come to an agreement with the US Food & Drug Administration (FDA) to conduct an additional Phase III trial of abiraterone acetate in prostate cancer. The currently ongoing and much in demand Phase III trial of abiraterone acetate was designed for prostate cancer survivors who [...]
A group of investigators, interested in the influence of lycopene on both the clinical and laboratory progression of advanced prostate cancer in men with hormone refractory prostate cancer, ran a small prospective Phase II pilot study. The researchers gave lycopene supplementation (15 mg) daily for 6 months to their trial subjects. They performed follow up [...]
Charles (Chuck) Maack, Prostate Cancer Advocate/Mentor from the Wichita Kansas Chapter of Us TOO sent me this follow-up to yesterday's post on Alpharadin. Interesting is this drug completed Phase II trials in Norway back in October 2007 involving 64 HRPC patients with more than twice as many patients receiving Alpharadin alive (10 of 33) two [...]
