bisphosphonates

Early Use of Zoledronic Acid (Zometa) in Men with Castration-Sensitive Prostate Cancer and Bone Metastases: Results of CALGB 90202 (Alliance).

We have long known that Zoledronic Acid (Zometa) decreases a man’s risk of developing skeletal-related events (SREs) in men with castration-resistant advanced prostate cancer (CRPC) and bone metastases. In a phase III study that evaluated efficacy and safety of earlier treatment with Zometa in men with advanced prostate cancer which is still castration-sensitive found that [...]

By Malecare|2017-10-19T10:50:06-04:00March 12th, 2013|Advanced Prostate Cancer, bisphosphonates, Clinical Trials, Clinical Trials, Drugs & Treatments, Uncategorized, Zometa|0 Comments

Some Side Effects of Androgen Deprivation Therapy (ADT) Induced by Estrogen Deficiency

Androgen deprivation therapy (ADT) is an old standby for the treatment of men with metastatic or advanced prostate cancer. We have long known that testosterone plays an integral role in the progression of prostate cancer, thus we often use it as an initial treatment for men who become metastatic. ADT is used both for men [...]

By Malecare|2017-10-19T10:51:01-04:00July 3rd, 2012|Advanced Prostate Cancer, bisphosphonates, Bone Mineral Density, Drugs & Treatments, General Information, Hormone Therapy, How We Live, Prostate Ponderings, Uncategorized, Understanding APC|0 Comments

Xgeva (Denosumab) Rejected By the FDA for Use in Men with Advanced Prostate Cancer Who Do Not have Bone Mets

Xgeva (denosumab), which has already been approved by the Food and Drug Administration (FDA) for the prevention fractures in men with advanced prostate cancer that has already migrated to the bone, has been rejected by the FDA to expand the use of the drug to delay the spread of tumors in men without metastases to [...]

By Malecare|2012-04-27T11:01:50-04:00April 27th, 2012|Advanced Prostate Cancer, bisphosphonates, Bone Metastases, denosumab - Xgeva, Drugs & Treatments, FDA, Uncategorized, Understanding APC|4 Comments

Osteonecrosis Of The Jaw While Taking Zometa & Xgeva

The use of denosumab (Xgeva) as an alternative to the more commonly prescribed zoledronic acid (Zometa) to slow down the development of bone metastases in men with advanced prostate cancer is becoming more common. The most common concern for men taking Zometa and now Xgeva has been osteonecrosis of the jaw. Osteonecrosis of the jaw [...]

By Malecare|2017-10-19T10:51:53-04:00December 12th, 2011|Advanced Prostate Cancer, bisphosphonates, denosumab - Prolia, denosumab - Xgeva, Drugs & Treatments, Uncategorized, Understanding APC, Zometa|9 Comments

XGEVA Delays The Onset Of Bone Metastases In Men With Non-Metastastic Castrate Resistant Prostate Cancer

Amgen announced that they have published the results from their Phase 3 trial (the '147 study) that evaluated XGEVA® (denosumab) for use in preventing or delaying the onset of bone metastases in men with non-metastatic castration-resistant prostate cancer (CRPC). The results were published in The Lancet. The study found XGEVA significantly prolonged bone metastasis-free survival, [...]

By Malecare|2020-02-04T10:43:48-05:00November 23rd, 2011|Advanced Prostate Cancer, bisphosphonates, Clinical Trials, Clinical Trials, denosumab - Xgeva, Drugs & Treatments, Metastases, Uncategorized, Understanding APC|2 Comments

On The Horizon- Coming Soon – Radium-223 (Alpharadin) A Bone Targeted Treatment for Advanced Prostate Cancer that Extends Life

At the recent European Multidisciplinary Cancer Congress in Stockholm, Dr Chris Parker from The Royal Marsden Hospital presented results of the phase 3 ALSYMPCA trial that showed both delayed time to first skeletal-related event (SRE) AND an overall survival (OS) benefit for those men with advanced prostate cancer taking radium-223 (Alpharadin). The real significance of [...]

By Malecare|2011-10-04T15:33:19-04:00October 4th, 2011|abiraterone acetate, Advanced Prostate Cancer, Alpharadin (radium-223), bisphosphonates, Cabazitaxel, Chemo Therapy Failure, Clinical Trials, Clinical Trials, denosumab - Xgeva, Drugs & Treatments, On The Horizon, Uncategorized, Zometa|1 Comment

Should Bisphosphonates Use Be Limited- An FDA Panel Waffles on Limiting Duration

A recent meeting of an FDA advisory committee has asked wants the FDA to limit the duration of bisphosphonate therapy for treatment of osteoporosis, but the committee could not agree on a time limit to recommend. […]

By Malecare|2011-09-13T10:46:54-04:00September 13th, 2011|Advanced Prostate Cancer, bisphosphonates, Bone Mineral Density, Drugs & Treatments, FDA, Uncategorized, Understanding APC, Zometa|0 Comments

On The Horizon – Xgeva (denosumab) To Prevent or Slow Down Bone Mets

Yesterday, Amgen announced that it had submitted a supplemental Biologics License Application (sBLA) to the U.S. Food and Drug Administration (FDA) to expand its license for XGEVA® (denosumab) to treat men with castrate-resistant prostate cancer to reduce the risk of developing bone metastases. If approved, XGEVA would be the first therapy licensed to prevent or [...]

By Malecare|2011-06-27T23:08:22-04:00June 27th, 2011|Advanced Prostate Cancer, bisphosphonates, Clinical Trials, Clinical Trials, denosumab - Prolia, denosumab - Xgeva, Drugs & Treatments, FDA, Metastases, On The Horizon, Uncategorized, Understanding APC|0 Comments

A Video on Bone Metastases & Zometa

I recently made a video with Dr. James Mckiernan of Columbia Presbyterian Hospital in New York City on the use of Zometa (zoledronic acid) to combat bone metastases in advanced prostate cancer that is castrate resistant. Novartis Oncology, the makers of Zometa, sponsored the video and it was produced on the Wego Health web page. [...]

By Malecare|2020-02-04T08:52:57-05:00May 2nd, 2011|Advanced Prostate Cancer, bisphosphonates, Drugs & Treatments, General Information, Me, Uncategorized, Understanding APC, Zometa|2 Comments

Should Men on ADT Take Calcium and Vitamin D Supplementation?

As usual with prostate cancer there is no general agreement about whether or not men who are on a hormone blockade (ADT) to treat prostate cancer should be taking calcium and vitamin D supplements, however there does seem to be some consensus that they should. Given that there are geographic and seasonal variations in vitamin [...]

By Malecare|2011-04-27T10:46:54-04:00April 27th, 2011|Advanced Prostate Cancer, bisphosphonates, denosumab - Prolia, Diet and Supplements, Drugs & Treatments, General Information, Uncategorized, Understanding APC, Zometa|1 Comment