Malecare, Author at malecare.org

Provenge Comes Closer to European Union Approval for Men with Advanced Prostate Cancer

It was announced today that the European Medicines Agency (EMA) Committee for Medicinal Products for Human Use (CHMP) has adopted a positive opinion recommending that PROVENGE® (autologous peripheral blood mononuclear cells activated with PAP-GM-CSF or Sipuleucel-T) be granted marketing authorization in the European Union (EU), for the treatment of asymptomatic or minimally symptomatic metastatic (non-visceral) [...]

By Malecare|2013-06-28T09:05:09-04:00June 28th, 2013|Advanced Prostate Cancer, CHMP, Drugs & Treatments, General Information, Provenge, Uncategorized, Understanding APC, vaccines|2 Comments

On the Horizon – Many More Novel Drugs for the Treatment of Advanced Prostate Cancer

There have been many potential targets identified for the treatment of advanced prostate cancer. Many of these targets are being actively explored with clinical trials designed to test some inhibitors of the targets. Antisense oligonucleotides (OGX-011) targets clusterin, a chaperone protein and OGX-427 which targets heat-shock protein 27 are among the inhibitors being evaluated. OGX-011 [...]

By Malecare|2017-10-19T10:49:43-04:00June 27th, 2013|Advanced Prostate Cancer, Clinical Trials, Clinical Trials, Combination Therapy, Custirsen, Drugs & Treatments, General Information, On The Horizon, Tasquinimod (TASQ), Uncategorized, Understanding APC|0 Comments

On the Horizon – Targeting Bones in the Treatment of Advanced Prostate Cancer

Osteoblasts and osteoclasts are the process that the body uses to breakdown old bone and then to rebuild it with new bone. c-Met is a tyrosine kinase expressed by osteoblasts and osteoclasts, and overexpressed by prostate cancer cells. This over expression leads to the eventual development of bone metastases. The experimental treatment known as Cabozantinib [...]

By Malecare|2017-10-19T10:49:44-04:00June 21st, 2013|Advanced Prostate Cancer, Bone Metastases, cabozantinib, Clinical Trials, Clinical Trials, Drugs & Treatments, On The Horizon, Uncategorized, Understanding APC|0 Comments

Laptop Computer Exposure Associated With Non-Thermal Effect on Sperm Quality & Maybe Prostate Cancer

Are you the kind of guy that uses his laptop computer in your lap? Many of us do this when we are in our car or even seated on our couch while we watch TV. If we don’t most of our children and granchildren do. According to research presented at the American Society for Reproductive [...]

By Malecare|2017-10-19T10:49:45-04:00June 20th, 2013|Advanced Prostate Cancer, genetics, Genomics, How We Live, Uncategorized, Understanding APC|0 Comments

What is the Current Role of Taxanes in the Treatment of Metastatic Prostate Cancer?

Since it FDA approval in 2004, docetaxel (a taxane based chemotherapy) has been the standard first-line chemotherapy for men with metastatic prostate cancer (mCRPC). Other than the trial of Provenge all the successful phase III trials conducted in mCRPC focused on men experiencing cancer progression after first-line docetaxel chemotherapy. The implication is that improving the [...]

By Malecare|2017-10-19T10:49:45-04:00June 19th, 2013|abiraterone acetate, Advanced Prostate Cancer, Alpha Emitting Radio Therapy, Alpharadin (radium-223), Cabazitaxel, Chemo Therapy, Chemo Therapy Failure, Clinical Trials, Clinical Trials, Drugs & Treatments, Enzalutamide (MDV-3100), Uncategorized, Understanding APC, Xofigo, Xtandi, Zytiga|2 Comments

PET/MR Imaging More Efficacious for Mapping Recurrent Prostate Cancer

Approximately one third of all men diagnosed and treated for prostate cancer will experience a recurrence of their prostate cancer! This is a shocking number, but it is a true number. It does not matter what the treatment a man has, the statistic holds up across all treatments. The first sign of a problem, a [...]

By Malecare|2020-02-04T10:44:08-05:00June 18th, 2013|adjuvant therapy, Advanced Prostate Cancer, Bio Chemical Recurrence, Choline C11, General Information, Research, salvage therapy, Uncategorized, Understanding APC|0 Comments

Start A Cure Project of the Day – Extending “Off Periods” of ADT

Start A Cure Research Project of the Day A Simple and Novel Approach to Enhance the Efficacy of Intermittent Androgen Deprivation Therapy for Prostate Cancer Patients There comes a time when most of us will go on to Androgen Deprivation Therapy (ADT). Depending upon your philosophy, your doctors philosophy and your numbers (Gleason grade and [...]

By Malecare|2020-02-04T10:44:04-05:00June 17th, 2013|Advanced Prostate Cancer, Bone Mineral Density, Research, Start A Cure, Uncategorized|0 Comments

Using Denosumab (Xgeva) To Combat Skeletal Complications in Prostate Cancer

Xgeva is a monoclonal antibody that inactivates RANKL, a protein that enhances osteoclast activity and survival. By inhibiting RANKL, Xgeva prevents skeletal-related events in men with bone metastasis from prostate cancer. Under no circumstances should a man who also has multiple myeloma use Xgeva. There have been studies that compared Xgeva to zolendronic acid (Zometa). [...]

By Malecare|2013-06-17T08:13:11-04:00June 17th, 2013|Advanced Prostate Cancer, Bone Metastases, denosumab - Prolia, denosumab - Xgeva, Drugs & Treatments, Metastases, Prolia (denosumab), Uncategorized, Understanding APC, Xgeva|0 Comments

DOD PCRP Gets Funded for the 2014 Budget Year

I have often discussed the importance of the Prostate Cancer Research Program (PCRP), which is a part of the Department of Defense (DOD) Medical Research Program. The program is geared to delivering funding for prostate cancer research that is translational, or will be quickly interpreted in the clinic. Like all other government funding it very [...]

By Malecare|2021-02-17T10:43:15-05:00June 14th, 2013|Advanced Prostate Cancer, Advocacy, DOD, Financial, General Information, Politics of Cancer, Research, Start A Cure, Uncategorized|0 Comments

Should Provenge be Used Before or After ADT in Men with Biochemical Prostate Cancer Recurrence?

Sequencing of the various new advanced prostate cancer treatments remains a hot topic in our community. What treatment should come first and will the combination of various treatments be even more effective? These types of questions are constantly buzzing around us and they will continue to as long as we develop new treatments. The only [...]

By Malecare|2020-02-04T11:49:24-05:00May 30th, 2013|Advanced Prostate Cancer, ASCO, Bio Chemical Recurrence, Clinical Trials, Clinical Trials, Combination Therapy, Drugs & Treatments, Hormone Therapy, Provenge, Uncategorized, Understanding APC|0 Comments

Malecare

About Malecare