Understanding APC

Enzalutamide (Xtandi) Improves The Quality of Life As Well As Extending Life In Men With Castrate Resistant Prostate Cancer

In clinical trials Enzalutamide (Xtandi) significantly increased the overall survival and radiographic progression-free survival of men when compared with placebo. The trial, called PREVAIL evaluated men who were asymptomatic and minimally symptomatic, chemotherapy-naive with metastatic castration-resistant prostate cancer. The researchers expanded the data analysis and evaluated the effect of Xtandi on the men’s health-related quality [...]

By Malecare|2020-02-04T11:37:28-05:00June 12th, 2015|Advanced Prostate Cancer, enzalutamide, Uncategorized, Understanding APC, Xtandi|0 Comments

How Men Can Preserve Their Emotional Well Being When Fighting Advanced Prostate Cancer -Ideas For Interventions

In a study performed in the UK researchers explored how men with advanced prostate cancer support their personal well being. The study analyzed the practices used by five (5) men with advanced prostate cancer to maintain their emotional wellbeing. Information about the men’s individual practices was taken from face-to-face, semi-structured, in-depth interviews with the five [...]

By Malecare|2020-02-04T11:37:32-05:00June 9th, 2015|Advanced Prostate Cancer, advanced prostate cancer support group, How We Live, mental health, Research, survivorship, Uncategorized, Understanding APC|2 Comments

More On The Efficacy Of Sipuleucel-T (Provenge) – It Works

Despite its approval five years ago sipuleucel-T (Provenge) remains one of the most controversial treatments available for men with castrate resistant metastatic prostate cancer (mCRPC). Provenge has its advocates (Full Disclosure- I am) and it has many detractors. The detractors argue that it doesn’t work and they hang their hat on the argument that it [...]

By Malecare|2020-02-04T11:45:00-05:00April 7th, 2015|Advanced Prostate Cancer, Drugs & Treatments, immunotherapy, Provenge, Uncategorized, Understanding APC|5 Comments

Lethal Advanced Prostate Cancer Has Inherently Heterogeneity And Can Spread From Other Metastatic Sites

We still have a lot to learn about how prostate cancer actually spreads, or metastasizes. Current theory holds that the primary tumor is probably most responsible for the development of distant metastases. In a new genomic analysis of tissue performed at the Johns Hopkins University using tissue from prostate cancer patients this paradigm has been [...]

By Malecare|2020-02-04T11:15:49-05:00April 2nd, 2015|Advanced Prostate Cancer, Drugs & Treatments, genetics, Metastases, Uncategorized, Understanding APC|0 Comments

Controversy at ASCO GU: Conflicting Randomized Trials on Docetaxel Plus ADT for Hormone Sensitive Metastatic Prostate Cancer *

Last year after the ASCO meeting in Chicago I declared that there was one particular presentation of the CHAARTED trial that would be a game changer for the treatment of newly diagnosed men with very significant prostate cancer. The game changer was that men diagnosed with significant disease and who were still ADT naive (not [...]

By Malecare|2020-02-04T10:39:13-05:00April 1st, 2015|Advanced Prostate Cancer, ASCO, Chemo Therapy, Clinical Trials, Clinical Trials, Drugs & Treatments, Hormone Therapy, taxotere, Uncategorized, Understanding APC|0 Comments

Detecting Prostate Cancer Cells in Blood Can Give An Early Warning of Treatment Failure and Shorten Clinical Trials

There is more evidence that the blood test used to count the number of cells circulating in the blood and shed from prostate tumors (circulating tumor cells or CTCs) can indicate whether a treatment is working or not working. A major new study showed that the number of these circulating tumor cells in the blood [...]

By Malecare|2017-10-19T10:47:29-04:00March 27th, 2015|Advanced Prostate Cancer, Clinical Trials, Clinical Trials, CTCs, General Information, On The Horizon, Uncategorized, Understanding APC, Zytiga|0 Comments

Is Cabazitaxel Before Docetaxel The Future Way To Go? *

Chemotherapy for prostate cancer is still limited to just two drugs, docetaxel (Taxotere) and cabazitaxel (Jevtana). Both of these chemotherapy drugs are taxanes, but they seem to be very different in their mode of action. A study published online in Clinical Cancer Research, indicates that cabazitaxel might be more effective for some men than docetaxel. [...]

By Malecare|2020-02-04T11:15:45-05:00February 18th, 2015|Advanced Prostate Cancer, Cabazitaxel, docetaxel, Drugs & Treatments, Jevtana, Research, taxanes, taxotere, Uncategorized, Understanding APC|0 Comments

*Does Avodart (Dutasteride) Allow Men on Intermittent Androgen Therapy To Have A Longer “Off Period”?

Researchers performed a randomized, placebo-controlled Phase II trial of men with localized prostate cancer and a rising prostate-specific antigen (PSA) level post-primary treatment. The men were randomized to receive Avodart (dutasteride @ 0.5 mg/day) or to receive a placebo. All of the men were receiving intermittent androgen deprivation therapy (IADT), which was stopped at month [...]

By Malecare|2015-02-17T15:32:35-05:00February 17th, 2015|2nd line hormone therapy, ADT, Advanced Prostate Cancer, Drugs & Treatments, Research, Uncategorized, Understanding APC|0 Comments

An Evaluation of Testosterone Flare During a Transition from Degarelix to Leuprolide in Men on ADT *

Many men with advanced prostate cancer who are on hormone therapy (ADT) use one of the newer drugs, degarelix (Firmagon) to achieve a state of castration. Degarelix is considered a superior drug for initiating ADT because it is not accompanied with a PSA flare that is common with the older luteinizing hormone-releasing hormone (LHRH) agonists [...]

By Malecare|2015-02-13T13:07:08-05:00February 13th, 2015|ADT, Advanced Prostate Cancer, degarelix, Drugs & Treatments, Firmagon (degarelix), Hormone Therapy, Uncategorized, Understanding APC|1 Comment

For Caregivers – Common Signs of Impending Cancer Death

Advanced Prostate cancer will eventually lead to our death. This is a sad truth that I know we all are very aware. In a study published Monday online in Cancer, researchers identify “eight specific physical signs” indicating a patient “with advanced cancer is entering the last days of life.” The signs that were identified were [...]

By Malecare|2021-02-17T10:30:01-05:00February 12th, 2015|Advanced Prostate Cancer, Research, Uncategorized, Understanding APC|0 Comments