Androgen deprivation therapy and mets

//Androgen deprivation therapy and mets

Johns Hopkins researcher finds relationship between androgen deprivation therapy (ADT) and the potential for cells to metastasize. This goes against the common practice of giving ADT to men at varying stages of prostate cancer. This is a very early study and must be verified but men may want to discuss this new information with their physicians. Do not panic. As the researchers say, discovery is far too preliminary for prostate cancer patients or physicians to stop using ADT. My thought is that they need to check additional cell lines and look for possible genetic associations. It may be that a subset of men have this issue.

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David Berman, an assistant professor of pathology, urology and oncology at The Johns Hopkins University School of Medicine, and his colleagues identified the unsuspected potential problem with treatments that suppress testosterone after discovering that the gene that codes for the protein, called nestin, was active in lab-grown human prostate cancer cells.

Curious about whether prostate cancer cells in people also produce nestin, the researchers looked for it in cells taken from men who had surgery to remove locally confined cancers of their prostates and found none. But when they looked for nestin in prostate cancer cells isolated from patients who had died of metastatic prostate cancer – in which cancer cells spread out from the prostate tumor – they found substantial evidence that the nestin gene was active.

To read the entire press release click here.

To read the Journal abstract and purchase the full text click here.

By | 2017-10-19T10:59:16+00:00 October 1st, 2007|Treatment News|3 Comments

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3 Comments

  1. C. R Deininger October 1, 2007 at 5:34 pm

    ADT works well. Was treated in 1999 and still clear. I am a good case in point. Dr Bob Leibowitz is the pioneer for this treatment. He is located in California in LA. Number is 310-229-3554. Look him up on the web.

  2. Jim Waldenfels October 2, 2007 at 9:51 pm

    I read the entire press release, and it is clear that this research on nestin is extremely preliminary. In the highly complex prostate cancer cellular environment, it is not evident that nestin makes any significant difference. As Dr. Berman said, more study is needed. I would say that a lot more study is needed.

    Since the press release raises some concern that androgen deprivation therapy (ADT) may be associated with promoting metastases, I personally consider it irresponsible that the release did not mention that ADT’s usual impact on metastases is to reduce or even eliminate metastases, which is a powerful counter to the speculation in the release.

    I have been on intermittent ADT for nearly eight years, very successfully, twice achieving nadirs of

  3. Jim Waldenfels October 9, 2007 at 3:46 pm

    (continued from previous)
    less than 0.01 ng/ml.

    As I understand it, when ADT fails, it is typically because it cannot control AIPC (androgen independent prostate cancer), not because metastases develop. Metastases typically do develop sometime later, after development of AIPC.

    Jim

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